Overview

With abundant vitamin C: spread of cancer cell prevented

Overview on cancer and effective alternative approaches

INDEX

› Introduction
› What is cancer?
› Risk factors
› Carcinogenesis
› Induction Mechanisms
› Symptoms e diagnosis
› Treatments and side effects
› Dr. Rath’s innovations
› About the authors
› Bibliography


Cancer research has been suffering from public and private bad research for some time. Medical decisions are systematically distorted for several reasons.

One reason is that pharmaceutical companies may interrupt research at any time and may forbid publication of data not in their favour (JAMA 2006;295(14):1641-1646. doi:10.1001/jama.295.14.1645).

It would be enough if governments obliged everyone (researchers, financiers and control boards like FDA) to publish all data related to research and trials performed, including those that do not meet initial research purposes.
It is inevitable that every drug having desired results has unpredictable toxic effects.

However, if there is no way to analyse all research data and tests, as they are not made public, it is impossible for a physician to assess drug prescription for the patient correctly.

Very – actually too often physicians and patients are not able to know all the real benefits and risks of taking certain chemical substances, produced to deliberately modify/alter our bodily and brain chemical/cellular functioning.

Whilst waiting for a remedy to a distorted and misrepresented research performed by economic interests and lack of regulation to safeguard patients from useless suffering and death, it is important to gain information on institutions, researchers and physicians, whose research is in no way connected to pharmaceutical companies and their representatives.

Outside pharmaceutical company turnovers, there is very little money available. This is the reason for the rise of international no profit organisations, to conduct independent research, such as Cochran Collaboration, and dr. Rath Research Institute that is self-financed through the Foundation distributing its own products.

INTRODUCTION

Cancer is one of man’s most feared diseases. According to the World Health Organisation, over ten million new cases of cancer are recorded every year and it is estimated that this number shall rise to 15 million by 2020. Six million people die of cancer round the world every year, equal to 12 % of total deaths.

In the year 2000, Germany records 400.000 new cases of cancer every year, according to R. Kock Institute data. Breast, prostate, lung, colon and rectal cancer are the most widespread. Funds allocated to “war on cancer” by the US administration, started in 1971 by president Nixon, have not found a definite solution to this increasing problem yet. Pharmaceutical company figures, on the other hand, account for the creation of a “cancer industry”, an activity with a yearly worldwide turnover of 500 billion dollars.

The diagram below shows which forms of cancer are thew most common for men and women.

cancer_statistics

The most frequent tumour sites as a percentage of all new cases of cancer in Germany 2008 (not including non-melanoma skin cancer).

Innovation introduced by Dr. Matthias Rath’s research on cancer allows for an effective natural control of this disease in an economical and safe manner. His research in cellular medicine and especially his discovery of how to circumscribe metastasis in a natural way, thus avoiding the side effects of conventional medication, open a new path to curing tumours and increasing hopes of controlling this very serious illness.

We here provide essential information on general aspects regarding cancer such as development, diagnosis, markers and healing possibilities with a conclusion describing the advantages of cellular medicine against conventional therapies.

WHAT IS CANCER?

The human body is composed of billions of cells. Cells normally divide, perform their function for a certain period and are then replaced by new cells.

MMPs-To grow and expand, cells have to dissolve their thick collagen matrix and the connective tissue. For this purposes, cell secrete specific enzymes, the matrix metalloproteinase (MMP).

In a healthy organism, MMP secretion occurs in a controlled manner in order to avoid long lasting damage to collagen.

However, some cells sometimes avoid a regular growth control, splitting also when it is not necessary. As time goes by, these cells amass and form a continuous mass: the tumour.

Matrix metalloproteinases (MMPs) promote growth of cancer cells

Matrix metalloproteinases (MMPs) promote growth of cancer cells through the interaction of extracellular matrix (ECM) molecules and integrins, cleaving insulin-like growth factors and shedding transmembrane precursors of growth factors, including transforming growth factor-alpha (TGF-alpha). MMPs promote angiogenesis by increasing the bioavailability of pro-angiogenic growth factors. MMPs also regulate invasion and migration by degrading structural ECM components — in particular, by cleaving laminin-5. IL-6R, interleukin-6 receptor; TGF-beta, transforming growth factor-beta; TNF, tumour necrosis factor. SOURCE: Nature.com

There are two types of tumours: benign and malignant. Benign tumours do not spread to other parts of the body, do not generally endanger the patient’s life and may be removed surgically.

Depending on the dimension of the tumour mass, these cancers may cause pain and compromise normal organ function.
Malignant tumours, on the other hand, are composed of cells that reproduce aggressively and uncontrollably.
Here below are the staging and prognosis criteria to identify cancer:

1) hyperplasia (excessive cell proliferation)
2) tumour colonisation (cancer cells invade neighbouring tissues)
3) metastasis ( migration of cancer cells to other parts of the body and growth of new life-threating tumours)

Similarly to benign tumours, also malignant tumours may cause pain and compromise normal body functions. In many cases, malignant tumours are life threatening.

All cancer cells, independently from their origin, are characterised by the same mechanisms:

they produce enormous quantities of enzymes (MMP) that entail a continuous dissolution of connective tissue.
These enzymes, which may be compared to “cutting tools”, favour detachment of cancer cells from the tumour mass and subsequent spreading in the body via blood and lymphatic liquid, to reach other organs.

Once in the blood and in the lymphatic liquid, which flow all over the body, cells reach all the other organs.
Lymph is a clear liquid that flows in the lymph nodules to remove impurities from organs. One of the functions of lymph nodules is filtering foreign bodies, such as cancer cells.

The presence of cancer cells in lymph nodules is an indicator of cancer formation in an organ and its spreading to other organs. The types of cancer that derive from hematopoietic cells are defined as leukaemia and lymphoma.

RISK FACTORS

Independent risk factors

Many types of human tumours are related to life styles. Among life style risk factors, we find smoking, alcohol abuse, excessive exposure to sunrays, insufficient physical activity, improper nutrition and lack of essential cell nutrients.

The rise in cancer risk may however also depend on insufficient consumption of fruit and vegetables, food that contains uncountable antioxidants, and on long period assumption of certain.

Other risk factors are greatly related to the environment. Among these, we find pesticides, automobile emissions and other toxic substances in air and water that damage the cells of the human body.

Certain chemical substances employed in some professions are also considered risk factors: asbestos, nickel, cadmium, radium, vinyl chloride and petrol.

Many drugs produced to fight cancer may trigger a new cancer type. Some viruses have been associated to some types of tumours: Epstein Barr virus, virus hepatitis B virus and T-cell leukaemia virus in man.

The outbreak of many tumour types is strictly connected with life style, nutritional habits and the environment. For these reasons, an adequate adjustment in daily habits may be in itself an adequate safeguard against tumours.

Genetic Factors
Unfortunately, certain cancer types are favoured by genetic and hereditary factors. This is a small, yet indicative percentage of colon, breast and ovary cancers.

CARCINOGENESIS

Radiations, chemical substances and viruses are cancer agents for both man and many species of animals. Although there are numerous different types of these agents, the effect on cellular layers is always the same: the production of neoplastic cells.

how-tumor-develops-dr-rathCancer cells are being continuously produced by the body during its life span. However, they do not all turn into malignant cells. Damages do not generally endure long, but if they are not correctly remedied, the second stage called latency (delayed) stage onsets.

A latency period may last years, before the tumour develops. During these period, different factors can speeden or slow the development of cancer pathology. Human cells have several protective mechanisms. One of these is repairing cellular damage.

All cells have enzymatic systems to remedy damages to DNA structures. When this mechanism fails, the immunity system kills abnormal cells. Furthermore, the human body may limit uncontrolled cell division by inhibiting enzymes that assimilate collagen.

The body defends itself also by strengthening connective tissue that surrounds the cancer cells, encapsulating them to prevent them from spreading. Several essential cellular nutrients function as inhibitors and modulators of tumour growth, for instance vitamins A, C and E, beta- carotene, lycopene, certain minerals and antioxidants.

A series of active vegetal principles (secondary vegetal substances) such as flavones, isoflavones, terpene, indols, resveratrol, diallil sulphide contained in garlic and onion, isothiocyanate in vegetables and several active principles in vegetables that have shown a protective effect against different types of cancer. Another powerful cancer inhibitor is amino acid lysine.

New-Cancer-Cure-Concept-VOC91This amino acid naturally controls cellular invasion and tissue propagation. Our body cannot produce many of these micronutrients and it is therefore easy to incur into a lack of these elements. Continuous procurement of all cell nutrients essential for cancer prevention is a means to control the illness. In this way, not all carcinogenic cells turn into malignant tumours.

INDUCTION MECHANISMS BY CARCINOGENIC AGENTS

In general terms, there are two types of carcinogenesis: the one that damages DNA directly (genotoxic carcinogenesis) and the one that damages DNA through other substances (non-genotoxic carcinogenesis).

Many carcinogens have to be initiated by a biotransformation to damage the body. Human cells are fitted with different mechanisms to initiate carcinogens. The variable occurrence of these mechanisms depends on an individual’s genetic constitution, life style and nutritional habits.

This is reason for each individual being differently predisposed to cancer. Carcinogenesis is a multi-phase process involving diverse interactions among genes, environment and metabolic factors.

In order to perform consequential analyses, this process has been divided into three stages:

  • initiation
  • promotion
  • progression.

This subdivision has led to the understanding of cancer development during experiments.

Initiation

In the initial stage, the carcinogen damages the DNA, directly or by adequate bio-activation. However, the cell is still able to repair the damaged DNA.
Should damage repair fail, genetically modified cells reformed. Some of these cells undergo such huge genetic damage that, in determined conditions, triggers a carcinogenesis process. These transformed cells, called initiated cells, are abnormal, but are not cancer cells yet.
However, these cells have many special properties, One of these properties is the capacity to multiply and originate focal areas (which generate focuses). These “islands” of focuses already constitute carcinogenic forms.

Promotion

Promoting substances are chemical agents that do not necessarily always cause damages. They induce the formation of cancer only if an initiating substance has spread in the body.

Promoting substances accelerate the growth of damages in a targeted manner and they then spread as focuses. The names of these damages depend on the organ in which they occur: nodules in the liver, breast or bladder; polyps in colon and papillomas (excrescences) on the skin.

Contrary to initiation that is a fast stage, promotion is a slower and longer process. This slow rate allows for a further intervention possibility. It has not been ascertained that any nodule, polyp or papilloma is a precursor of cancer; however, these damages may trigger some forms of cancer.

Progression

Progression is the less studied stage of the cancergenic process and it is concerned with changes in genetic material by means of which focal excrescences turn into cancer. However, a carcinoma is not the terminal stage.
The disease develops constantly with relentless growth of cancer cells that spread and eventually form metastasis.

Anticancer Substances

It is well known that oxidative damages in early and late stages of carcinogenesis play an important role in these processes.
For this reason, antioxidants may be very effective in slowing down the cancergenic process, particularly in advanced stages. Other essential cell nutrients, mainly lysine amino acid, can prevent propagation of cancer cells by different mechanisms.

Strengthening and stabilisation of collagen and connective tissue surrounding cells are some of the mechanisms. Some essential cell nutrients can inhibit collagen-assimilating enzymes, whereas others favour synthesis or give connective tissue excellent structure and functionality.

An excellent connective tissue structure is an essential prerequisite to ensure a balanced cell division and to safeguard the activity of different cell growth factors and cytokines. Cytokines are crucial in the initiation, promotion and progression stages of cancer.

Anticarcinogenic action

Essential cell nutrients that have the capacity to reduce cancer risks and to inhibit the progression of the disease, are roughly subdivided into four main categories according to the development stages, exercise their own protective function.

A) Inhibitors
This category includes essential cell nutrients that prevent the formation of carcinogens, like vitamin C (ascorbic acid), vitamin E (alfa-tocopherol) etc.

B) Blockers
This is the second group of anticarcinogenes, probably the most studied. These blockers prevent carcinogens from damaging DNA. Some examples: indol-3-carbinol, Butylated hydroxyanisole, Butylated hydroxytoluene and ellagic acid.

C) Inhibiting substances
The substances that belong to this group are frontline inhibitors of tumour promotion. Among these: selenium salt, retinoids, carotenoids, butylated hydroxyanisole, benzyl isothiocyanate etc.

D) Anti-metastasis substances
These substances control, with priority and in a natural way, cellular invasion and cell propagation in tissue. Anti-metastasis substances are lysine amino acid and vitamin C.

SYMPTOMS AND DIAGNOSIS

SYMPTOMS
The cell growth process entails multiple alarming symptoms: the manifestation of tumours (e.g. in the breast), verrucas or birthmarks that change shapes. Wounds that do not heal, persistent cough or raucousness, changes in intestinal or urinary functions, anomalous blood in faeces, hematomas not caused by traumas, digestive problems or difficulty in swallowing, weight variations that are apparently inexplicable.
These symptoms are not always associated to cancer; only laboratory tests and exams can define a final diagnosis.

DIAGNOSIS
In some cases, it is possible to diagnose cancer before it reaches complete development. A specialist’s visit for cancer diagnosis is called screening. A physician can search for the presence of cancer during routine checks and prescribe specific tests for cancer markers or other tests.

BREAST CANCER
Breast cancer is diagnosed by means of a mammography. However, this method involves many problems (false positive results, risk of cancer due to radiating therapy).

Cervix Cancer
Smear tests are used to diagnose cervix cancer. The sample of cells is analysed by a pathologists to identify abnormal changes.

Colon Cancer
There is a series of tests to recognise this tumour. The simplest is the faecal occult blood test that verifies the presence of occult blood in faeces and rectum. Another test is rectal and sigmoid examination. Any abnormal tissue is identified, a sample taken and examined. The digital rectal examination is a common procedure with which a physician palpates abnormal rectal points.

Prostate Cancer
Rectal examination and prostate-specific antigen range detect prostate cancer.

Lung Cancer
Lung cancer is detected by means of chest X-ray and cytological sputum test (sputum examination). To diagnose cancer, the following methods are used: Tumor Markers

Tumour markers in the blood and urine provide important information on a person’s health. Examples of these markers are paraproteins in the case of multiple myeloma or macroglobulinemia, human chorionic gonadotropin (HCG) in cases of choriocarcinoma and testicular cancer, la prostate alkaline phosphatase and for prostate cancer.

Tumours secrete foetal antigens that allow monitoring and progression of the disease and successful therapy. Some of these antigens are: alpha-fetoprotein in cases of hepatoma, testicular cancer, teratogenic carcinoma (or embryonic), some cases of stomach cancer, del ovary carcinoma antigen CA125 and carcinoembryonic antigen (CEA) in colon, lung, breast and pancreas cancer. There is also a series of other tumour markers.

DIAGNOSTIC METHODS

Imaging

Diagnostic imaging is employed to localise tumours precisely. Standard methods are radiography, computerised axial tomography (CT o ACT), la contrastography, ultrasonography and nuclear magnetic resonance (NMR). These exams localise cancer, highlight connection with other organs and show any trace of metastasis in the body.

Biopsy

Biopsy is a method to take some cells from tissue by endoscopy, needle biopsy or other biopsy. The pathologist analyses the tissue under a microscope to determine whether the tumour is benign or malignant.

Staging

A process detects the extension of the cancer and allows the doctor to formulate a prognosis.

Prognosis

A prognosis is a prediction of the development of the disease and it depends on different factors, for instance the type of cancer, the extension, the pathological state, the degree of local invasion and the presence of metastasis in other parts of the body. Other factors to establish prognosis is the general health of a patient and his nutrition before and after therapy.

ANTICANCER THERAPY AND SIDE EFFECTS

Cancer has been treated with standard methods such as surgery, chemotherapy, and radiotherapy for years. The most used therapies, i.e. chemotherapy and radiotherapy, damage both cancer and healthy cells.
( [-])
Examples of side effects following chemotherapy and radiotherapy
Anaemia
Bleeding
Heart damages
Infections
Liver and kidney damages

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These therapies entail serious side effects that in different ways damage a patient’s general health conditions. Therefore, healing is difficult and often impossible. Furthermore, damages to DNA, induced by chemotherapy and radiotherapy, may trigger other types of cancer.

It is important to state that these therapies do not affect metastasis, the main cause of death in cancer patients. The destruction of connective tissue in the body and damages to DNA by these medications, favour the spreading of cancer, and it is the formation of metastasis that is still being fought in cancer.

Cancer patients, who realise that conventional methods aim at treating the symptom and do not lead to healing, resort to alternative methods, which however lack scientific support and proof.

Cellular medicine differs from other alternative medicine as it is based on science and it is documented. The fundamental point of this approach is the fight against metastasis that plays a decisive role in tumour pathology.

This type of treatment depends on many factors, such as the extension of the tumour, position, stage and above all the patient’s general health. Statistically the last ten years have recorded a drop in some types of cancer (e.g. lung cancer).

This result may be attributed to a general implementation of prevention actions (e.g. Giving up smoking) rather than to the discovery of new treatments.

Surgery
A cancer patient is assisted mainly by a team of specialists such as surgeons, radiologists and oncologists.
Surgery may be performed independently or in combination with other therapy.

Surgery is often the best in case where the tumour has not spread in the body. The surgeon removes the tumour and a small part of the surrounding tissues in order to remove all cancer cells. The consequences of this type of intervention depend on several factors such as the dimension of the tumour, its position and the patient’s general health.

OBSERVATIONS:
Removal of a tumour mass does not guarantee the total removal of cancer cells from blood and tissue. The remaining cancer cells may cause new tumours. The healing process of tissue that has undergone damage and chemical substances during the operation (e.g. anaesthesia) adds additional stress to the body. To speeden the healing process and avoid the rise of new tumours it is necessary to provide the body with additional essential cell nutrients, vital substances that inhibit the growth of cancer cells, improve the functioning of the immunity system and reconstruct connective tissue.

CHEMIOTHERAPY
Chemotherapy employs one or more toxic substances with the purpose of annihilating or preventing propagation of cancer cells. These toxic substances reach all body cells, not only cancer cells.
Chemotherapy may be combined with other types of therapy. In neoadjuvant chemotherapy, drugs are used before surgery in order to atrophy the tumour.

In neoadjuvant therapies, on the other hand, the drug is given after surgery in order to prevent resurgence of cancer. In some cases, chemotherapy is used to overcome the symptoms of the disease. Drugs are usually given by intravenous injection, orally or injected into the muscle or skin.

Chemotherapy compromises cancer cells as well as other cells.

Side effects are: hair loss, nausea, diarrhoea, and mouth and lip inflammation.
Long-term side effects are loss of reproduction capacity, irregular menstruation, hot flushes and vaginal dryness. Chemotherapy causes side effects that require the use of other drugs and damage the immunity system for a long time. The body is therefore enfeebled in its fight against cancer.

OBSERVATIONS:
Chemotherapy damages all the cells and the entire organism and rarely leads to complete healing. It damages the healthy cells that divide rapidly (hair, gastric mucous and bone marrow) and causes anaemia, hair loss and gastric haemorrhage. Chemotherapy favours the development of new types of tumour, damages the immunity system and organs. It also eases the invasion of cancer cells by activating enzymes that are used by the cancer cells to propagate inside the organism. To keep the devastating effects of chemotherapy under control, additional drugs and therapy are prescribed to sooth the symptoms and ensure pharmaceutical companies with enormous earnings. Cancer has a current turnover of 500 billion dollars a year.

Chemotherapy and dietary supplements

Dietary supplements are necessary to facilitate healing and avoid the formation of new tumours. During chemotherapy, physicians discourage the use of antioxidants, as they may compromise therapy.
However, many studies have shown that antioxidants have two positive actions: they protect healthy cells against damages and at the same time, they have a pre-oxidant effect on cells damaged by chemotherapy poisons.

An article that has recently been published on “Journal of the American College of Nutrition” confirms the use of dietary supplements in patients who have undergone chemotherapy. According to this study, vitamin C by endovenous injection in two patients resulted in a drop of tumour markers (reduction CA-125 from 999 to 5).

Besides, no unfavourable effects to chemotherapy were recorded. These patients have not had any relapses for over three years.

Furthermore, this study proves that in order not to minimize the effects of chemotherapy discouraging vitamins in oncological patients is completely unfounded.

Although it is not the first study on cancer therapy through vitamin C and other essential cell nutrients, this study comes from one of the most advanced institutes, the School of Medicine of the university of Kansas.

RADIOTHERAPY
Radiotherapy uses high energy X-rays to destroy cancer cells. In some types of cancer, radiotherapy may be used as primary therapy instead of surgery.

Radiating therapy may be performed before surgery to reduce the dimension of a tumour and ease removal, or following surgery to destroy any surviving cancer cells.

Irradiation of a patient is performed very precisely, to avoid damaging surrounding cells: it may be external, internal or both. External radiotherapy consists in irradiating the tumour directly by means of a machine; the rays do not remain in the body after irradiation.

Radiotherapy consists in inserting radioactive material directly into the tumour by means of
radioactive implants (known as brachytherapy) that involve the insertion of metal wires, seeds or tubes near the cancerous cells.

Side effects of radiotherapy depend on the dosage and duration of administration, but according to experience, patients are exhausted at the end of the session.
External radiation makes the skin dark, rough, dry and itchy. There may also be temporary hair loss and drop in hematic cells.

According to general opinion, oncological patients reduce the effect of radiotherapy by taking supplementary antioxidants as these substances protect cancer cells.

There are however several studies that document the double action of antioxidants on healthy and cancer cells: on one hand they protect healthy cells against damage and on the other they have a pre-oxidising effect on damaged cells, speeding cellular death induced by radiotherapy.

There is no health recovery or healing when patients stop taking these useful antioxidants during radiotherapy.

OBSERVATIONS:
Radiotherapy modifies healthy DNA irreversibly and may represent the starting point for other types of tumours. Furthermore, radiotherapy stimulates the growth of enzymes used by cancer cells to spread in the organism, thus facilitating .Radiotherapy reduces immune defences and compromises recovery. To enable the organism to heal and limit new cancer cell formation it is necessary to take supplements, especially essential cell nutrients to inhibit the growth of cancer cells, improve the functioning of the immune system and reconstruct connective tissue.

HORMONE THERAPY
Hormone therapy is used in hormone-dependant tumours. This therapy envisages administration of drugs that stop hormone production. Alternatively, surgery removes the organ producing the specific hormones Hormone therapy is generally used in cases of breast, prostate, ovary and uterine cancer. Side effects of hormone therapy are: weight gain, nausea, vomit, hot flushes and liquid retention. Hormone therapy in women may cause irregular menstruation, vaginal dryness, weight gain or impaired fertility. In men, it may cause low libido and impotence.

BIOLOGICAL THERAPY
Biological therapy, also known as immunotherapy, uses man’s characteristic immune system to combat the disease or to protect the body from side effects and other forms of cancer. The therapy involves the use, for example, of monoclonal antibodies, interferon and several interleukins that raise the number of white blood cells to combat cancer. Possible side effects are: nausea, vomiting, diarrhoea, fever, asthenia, flu-like symptoms and loss of appetite.

HEAT AND COLD THERAPY
To speeden cell death, the tumour is heated to 41°C, by means of drugs and radiotherapy. In some cases, cells are destroyed locally by means of laser or cryotherapy (cold induced by liquid nitrogen). Long-term results are not effective, as cancer cells develop resistance against high temperatures.

COMPLEMENTARY AND ALTERNATIVE MEDICINE
Complementary and alternative medicine employs treatments and therapies that traditional medicine does not envisage. These therapies may be used singularly or associated with traditional methods (“integrated” method). Herb based treatments, homeopathy, acupuncture, macrobiotic nutrition and spiritual healing are some of these methods. These new approaches have recorded an increasing interest and are effective in some patients. However, there is no scientific evidence of their efficacy.

INNOVATIONS OF Dr RATH’S CELLULAR MEDICINE IN ONCOLOGICAL RESEARCH

Dr. Matthias Rath’s pioneer cellular approach has been successful in seeking natural methods to correct metabolic disorders in several chronic diseases.

This approach provides the fundamentals to develop the possibility of limiting tumour progression and the formation of metastasis through the use of vitamins and other natural essential cellular nutrients.
Research on essential nutrients Epigallo-catechi-gallato (the verde), quercitina. (Epigallocatechin gallate (green tea), quercitin)
Cellular medicine uses the synergy of essential cellular nutrients, which play a significant role in patient survival, to control the growth and diffusion of cancer.
“The importance of optimal quality of extracellular matrix to inhibit tumour growth and metastasis”: a manuscript by Dr. Rath published in 1992 emphasized the importance of lysine and vitamin C.
These two essential cell nutrients can inhibit the weakening of extra cellular matrix and be decisive in controlling cancer cell invasion of the body.

ANTICANCER THERAPY AND SIDE EFFECTS
Cancer has been treated with standard methods such as surgery, chemotherapy, and radiotherapy for years. The most used therapies, i.e. chemotherapy and radiotherapy, damage both cancer and healthy cells.
( [-])
Examples of side effects following d chemotherapy and radiotherapy
Anaemia
Bleeding
Heart damages
Infections
Liver and kidney damages
@@@@@@@@@@@@@@@@+++++++++
Damages to nervous system
(neurological-cognitive side effect symptoms associated to chemotherapy)
Vertigo
Side effects of conventional anti-cancer therapy are so numerous and serious to be subject of specific studies, as in the article on the left.
@@@@@@@@@@@@@@
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( [-])

These therapies entail serious side effects that in different ways damage a patient’s general health conditions. Therefore, healing is difficult and often impossible. Furthermore, damages to DNA, induced by chemotherapy and radiotherapy, may trigger other types of cancer.
It is important to state that these therapies do not affect metastasis, the main cause of death in cancer patients. The destruction of connective tissue in the body and damages to DNA by these medications, favour the spreading of cancer, and it is the formation of metastasis that is still being fought in cancer.
Cancer patients, who realise that conventional methods aim at treating the symptom and do not lead to healing, resort to alternative methods, which however lack scientific support and proof.
Cellular medicine differs from other alternative medicine as it is based on science and it is documented. The fundamental point of this approach is the fight against metastasis that plays a decisive role in tumour pathology.
This type of treatment depends on many factors, such as the extension of the tumour, position, stage and above all the patient’s general health. Statistically the last ten years have recorded a drop in some types of cancer (e.g. lung cancer).
This result may be attributed to a general implementation of prevention actions (e.g. Giving up smoking) rather than to the discovery of new treatments.
Surgery
A cancer patient is assisted mainly by a team of specialists such as surgeons, radiologists and oncologists.
Surgery may be performed independently or in combination with other therapy. Surgery is often the best in case where the tumour has not spread in the body. The surgeon removes the tumour and a small part of the surrounding tissues in order to remove all cancer cells. The consequences of this type of intervention depend on several factors such as the dimension of the tumour, its position and the patient’s general health.
OBSERVATIONS:
Removal of a tumour mass does not guarantee the total removal of cancer cells from blood and tissue. The remaining cancer cells may cause new tumours. The healing process of tissue that has undergone damage and chemical substances during the operation (e.g. anaesthesia) adds additional stress to the body. To speeden the healing process and avoid the rise of new tumours it is necessary to provide the body with additional essential cell nutrients, vital substances that inhibit the growth of cancer cells, improve the functioning of the immunity system and reconstruct connective tissue.

CHEMIOTHERAPY
Chemotherapy employs one or more toxic substances with the purpose of annihilating or preventing propagation of cancer cells. These toxic substances reach all body cells, not only cancer cells.
Chemotherapy may be combined with other types of therapy. In neoadjuvant chemotherapy, drugs are used before surgery in order to atrophy the tumour.
In neoadjuvant therapies, on the other hand, the drug is given after surgery in order to prevent resurgence of cancer. In some cases, chemotherapy is used to overcome the symptoms of the disease. Drugs are usually given by intravenous injection, orally or injected into the muscle or skin.
Chemotherapy compromises cancer cells as well as other cells.
Side effects are: hair loss, nausea, diarrhoea, and mouth and lip inflammation.
Long-term side effects are loss of reproduction capacity, irregular menstruation, hot flushes and vaginal dryness. Chemotherapy causes side effects that require the use of other drugs and damage the immunity system for a long time. The body is therefore enfeebled in its fight against cancer.
OBSERVATIONS:
Chemotherapy damages all the cells and the entire organism and rarely leads to complete healing. It damages the healthy cells that divide rapidly (hair, gastric mucous and bone marrow) and causes anaemia, hair loss and gastric haemorrhage. Chemotherapy favours the development of new types of tumour, damages the immunity system and organs. It also eases the invasion of cancer cells by activating enzymes that are used by the cancer cells to propagate inside the organism. To keep the devastating effects of chemotherapy under control, additional drugs and therapy are prescribed to sooth the symptoms and ensure pharmaceutical companies with enormous earnings. Cancer has a current turnover of 500 billion dollars a year.

Chemotherapy and dietary supplements
Dietary supplements are necessary to facilitate healing and avoid the formation of new tumours. During chemotherapy, physicians discourage the use of antioxidants, as they may compromise therapy.
However, many studies have shown that antioxidants have two positive actions: they protect healthy cells against damages and at the same time, they have a pre-oxidant effect on cells damaged by chemotherapy poisons.
An article that has recently been published on “Journal of the American College of Nutrition” confirms the use of dietary supplements in patients who have undergone chemotherapy. According to this study, vitamin C by endovenous injection in two patients resulted in a drop of tumour markers (reduction CA-125 from 999 to 5). Besides, no unfavourable effects to chemotherapy were recorded. These patients have not had any relapses for over three years.
Furthermore, this study proves that in order not to minimize the effects of chemotherapy discouraging vitamins in oncological patients is completely unfounded.
Although it is not the first study on cancer therapy through vitamin C and other essential cell nutrients, this study comes from one of the most advanced institutes, the School of Medicine of the university of Kansas.

RADIOTHERAPY
Radiotherapy uses high energy X-rays to destroy cancer cells. In some types of cancer, radiotherapy may be used as primary therapy instead of surgery.
Radiating therapy may be performed before surgery to reduce the dimension of a tumour and ease removal, or following surgery to destroy any surviving cancer cells.
Irradiation of a patient is performed very precisely, to avoid damaging surrounding cells: it may be external, internal or both. External radiotherapy consists in irradiating the tumour directly by means of a machine; the rays do not remain in the body after irradiation.
Radiotherapy consists in inserting radioactive material directly into the tumour by means of
radioactive implants (known as brachytherapy) that involve the insertion of metal wires, seeds or tubes near the cancerous cells.
Side effects of radiotherapy depend on the dosage and duration of administration, but according to experience, patients are exhausted at the end of the session.
External radiation makes the skin dark, rough, dry and itchy. There may also be temporary hair loss and drop in hematic cells.
According to general opinion, oncological patients reduce the effect of radiotherapy by taking supplementary antioxidants as these substances protect cancer cells. There are however several studies that document the double action of antioxidants on healthy and cancer cells: on one hand they protect healthy cells against damage and on the other they have a pre-oxidising effect on damaged cells, speeding cellular death induced by radiotherapy.
There is no health recovery or healing when patients stop taking these useful antioxidants during radiotherapy.
OBSERVATIONS:
Radiotherapy modifies healthy DNA irreversibly and may represent the starting point for other types of tumours. Furthermore, radiotherapy stimulates the growth of enzymes used by cancer cells to spread in the organism, thus facilitating .Radiotherapy reduces immune defences and compromises recovery. To enable the organism to heal and limit new cancer cell formation it is necessary to take supplements, especially essential cell nutrients to inhibit the growth of cancer cells, improve the functioning of the immune system and reconstruct connective tissue.
HORMONE THERAPY
Hormone therapy is used in hormone-dependant tumours. This therapy envisages administration of drugs that stop hormone production. Alternatively, surgery removes the organ producing the specific hormones Hormone therapy is generally used in cases of breast, prostate, ovary and uterine cancer. Side effects of hormone therapy are: weight gain, nausea, vomit, hot flushes and liquid retention. Hormone therapy in women may cause irregular menstruation, vaginal dryness, weight gain or impaired fertility. In men, it may cause low libido and impotence.

BIOLOGICAL THERAPY
Biological therapy, also known as immunotherapy, uses man’s characteristic immune system to combat the disease or to protect the body from side effects and other forms of cancer. The therapy involves the use, for example, of monoclonal antibodies, interferon and several interleukins that raise the number of white blood cells to combat cancer. Possible side effects are: nausea, vomiting, diarrhoea, fever, asthenia, flu-like symptoms and loss of appetite.

HEAT AND COLD THERAPY
To speeden cell death, the tumour is heated to 41°C, by means of drugs and radiotherapy. In some cases, cells are destroyed locally by means of laser or cryotherapy (cold induced by liquid nitrogen). Long-term results are not effective, as cancer cells develop resistance against high temperatures.

COMPLEMENTARY AND ALTERNATIVE MEDICINE
Complementary and alternative medicine employs treatments and therapies that traditional medicine does not envisage. These therapies may be used singularly or associated with traditional methods (“integrated” method). Herb based treatments, homeopathy, acupuncture, macrobiotic nutrition and spiritual healing are some of these methods. These new approaches have recorded an increasing interest and are effective in some patients. However, there is no scientific evidence of their efficacy.

INNOVATIONS OF Dr RATH’S CELLULAR MEDICINE IN ONCOLOGICAL RESEARCH
Dr. Matthias Rath’s pioneer cellular approach has been successful in seeking natural methods to correct metabolic disorders in several chronic diseases.

This approach provides the fundamentals to develop the possibility of limiting tumour progression and the formation of metastasis through the use of vitamins and other natural essential cellular nutrients.
Research on essential nutrients Epigallo-catechi-gallato (the verde), quercitina. (Epigallocatechin gallate (green tea), quercitin)
Cellular medicine uses the synergy of essential cellular nutrients, which play a significant role in patient survival, to control the growth and diffusion of cancer.
“The importance of optimal quality of extracellular matrix to inhibit tumour growth and metastasis”: a manuscript by Dr. Rath published in 1992 emphasized the importance of lysine and vitamin C.
These two essential cell nutrients can inhibit the weakening of extra cellular matrix and be decisive in controlling cancer cell invasion of the body.
In-depth *********
Subsequent scientific studies have discovered the role of a combination of essential cellular nutrients that control enzyme activity effectively (MMP) and halt the penetration of cancer cells in the tissue. Lysine is a natural blocker of collagen digestion; it inhibits enzymes that assimilate collagen, responsible for the dissolution of collagen and other components of cellular matrix.

OBJECTIVES OF CELLULAR MEDICINE:
1) encapsulating the tumour by means of:
a. inhibition of excessive breakdown of the extracellular matrix
b. strengthening and optimisation of the extracellular matrix structure
2) selective destruction of cancer cells without compromising healthy cells
3) obstruction of inflammations and formation of new blood vessels that stimulate tumour growth.
1) Natural strengthening and construction of a healthy extracellular matrix
An excellent collagen structure and production as well as other components of the extracellular matrix are decisive for cellular metabolism stability and for a controlled cell growth. Vitamin C is important for the production and structure of collagen. This essential cellular nutrient acts as a powerful antioxidant as it intercepts free radicals and protects cell structures against damages. Amino acids lysine and proline are fundamental elements of collagen and constitute about one third of all amino acids contained in collagen. Hydroxylation dependent on vitamin C of these amino acids is decisive in maintaining ideal collagen formation.
2) Natural selective destruction of cancer cells

Many essential cellular nutrients are able to induce programmed cancer cell death (apoptosis). They behave like selective cancer poisons that however do not compromise healthy cells. The most well-known and studied example is vitamin C and its derivatives, like ascorbilpalmitate.

3) Prevention of blood vessel formation in blood vessels

A tumour with a diameter of over 0.5 mm stands no chance of survival unless it develops an independent circulatory system to procure nutritional substances
and remove waste products. The new blood vessels derive from endothelial cells that move and multiply to build a new structure. To start this process (angiogenesis) cancer cells secrete vascular endothelial growth factors that lead to the development of new blood vessels.
Essential cellular nutrients like vitamin C, lysine, proline and epigallocatechingallate can regulate both processes that play a very important role in the formation of new blood vessels in the tumor. See list of references to scientific research.
http://www.phytobiologicals.com/en/research.html

SYNERGY OF ESSENTIAL CELLULAR NUTRIENTS FOR TUMOR SPREADING AND GROWTH CONTROL:
The Scientific Evidence
Starting from Dr. Rath’s basic principles of cellular medicine synergies of essential cellular nutrients has been developed to control the penetration of cancer cells in the organism.

Lysine and vitamin C are powerful natural inhibitors of the enzymes that assimilate collagen and also play a crucial role in optimal collagen production and functioning. This group of synergies includes proline amino acids, epigallocatechingallate and other essential cellular nutrients.

The crucial elements in inhibiting invasion by cancer cells are lysine and vitamin C (ascorbic acid) that, although of vital importance, are not produced by the human body.
A chronic lack of lysine and vitamin C may explain how tumour progression is eased by a lack of essential cellular nutrients, above all if this deficit is present in the critical stages of initiation and propagation.

Lysine is the most effective essential cellular nutrient to block the collagen-digesting enzyme.
Lysine, a natural enzymatic blocker, has to be taken with food.
Lysine blocks anchor points of the enzyme so that that cannot feed on the tissue.
Enzyme that digests collagen
Prevention of uncontrolled collagen destruction
Lysine blocking
Activation of plasmin genes
Enzyme
Pro-collagenases Plasmin

How lysine blocks collagen digestion
Enzyme digestion of collagen and blocking with lysine
———————–+++++++++++++++++++++++

1) Natural strengthening and construction of a healthy extracellular matrix
An excellent collagen structure and production as well as other components of the extracellular matrix are decisive for cellular metabolism stability and for a controlled cell growth. Vitamin C is important for the production and structure of collagen. This essential cellular nutrient acts as a powerful antioxidant as it intercepts free radicals and protects cell structures against damages. Amino acids lysine and proline are fundamental elements of collagen and constitute about one third of all ammmino acids contained in collagen. Hydroxylation dependent on vitamin C of these amino acids is decisive in maintaining ideal collagen formation.
2) Natural selective destruction of cancer cells

Many essential cellular nutrients are able to induce programmed cancer cell death (apoptosis). They behave like selective cancer poisons that however do not compromise healthy cells. The most well-known and studied example is vitamin C and its derivatives, like ascorbilpalmitate.
3) Prevention of blood vessel formation in blood vessels

A tumour with a diameter of over 0.5 mm stands no chance of survival unless it develops an independent circulatory system to procure nutritional substances
and remove waste products. The new blood vessels derive from endothelial cells that move and multiply to build a new structure. To start this process (angiogenesis) cancer cells secrete vascular endothelial growth factors that lead to the development of new blood vessels.
Essential cellular nutrients like vitamin C, lysine, proline and epigallocatechingallate can regulate both processes that play a very important role in the formation of new blood vessels in the tumor. See list of references to scientific research.
SYNERGY OF ESSENTIAL CELLULAR NUTRIENTS FOR TUMOR SPREADING AND GROWTH CONTROL:
The Scientific Evidence
Staring from Dr. Rath’s basic principles of cellular medicine synergies of essential cellular, nutrients have been developed to control the penetration of cancer cells in the organism.
Lysine and vitamin C are powerful natural inhibitors of the enzymes that assimilate collagen and also play a crucial role in optimal collagen production and functioning. This group of synergies includes proline amino acids, epigallocatechingallate and other essential cellular nutrients. The crucial elements in inhibiting invasion by cancer cells are lysine and vitamin C (ascorbic acid) that, although of vital importance, are not produced by the human body.
A chronic lack of lysine and vitamin C may explain how tumour progression is eased by a lack of essential cellular nutrients, above all if this deficit is present in the critical stages of initiation and propagation.
Avoiding the invasion of cancer cells.

Scientists at Matthias Rath Inc. elaborated a model in which cancer cells with a central collagen matrix were incubated with different nutritional substances.
The matrix corresponds to the state of connective tissue in the human body. Tube A does not contain essential cellular nutrients, whereas tube B contains vitamin C, lysine, proline and EGCG.

These essential cellular nutrients were used both individually and in combined. Following incubation, the cancer cells that migrated through the matrix were colour marked and counted. The experiments delivered surprising results.
A simple combination of essential cellular nutrients was able to hinder the entrance of cancer cells into the collagen matrix.

A combination of essential cellular nutrients blocks the entrance of different cancer cells. Entrance blocked in:
• colon cancer
• prostate cancer, androgen-sensitive
• prostate cancer, androgen-resistent
• synovial carcinoma
• breast cancer, oestrogen-negative
• breast cancer, oestrogen-positive
• liver cancer
• fibro sarcoma
• melanoma
• pancreas

The following observations show the capacity of breast cancer cells MDA-MB-231 to penetrate into connective tissue, with and without added essential cellular nutrients penetrate.

IMG BRESTCANCER CELLS

ENZYMATIC DESTRUCTION OF EXTRACELLULAR MATRIX (MMP action)
Similarly, to other organs, tumours are also surrounded by a collagen network and connective tissue, called extracellular matrix. The extracellular matrix functions as a sort of barrier: it limits tumour growth and inhibits spreading to other body parts.
Cancer cells secrete a series of zinc-dependant enzymes, the so-called matrix metalloproteinases (MMP), which assimilate the extracellular matrix. MMPs have been identified as enzymes that dissolve the extracellular matrix and other important membranes. This factor allows the spreading of cancer cells.
There are different types of MMPs that contribute to cancer spreading.
The main cancer types, MMP-2 and MMP-9 are the most important enzymes in tumour metastasis. It has been shown that the synergy composition of essential cellular nutrients may inhibit MMP activity and the invasion of cancer cells (two essential aspects in anticancer therapy) in a series of human cancer lines, among which epidermis, liver, breast, prostate, rectum, fibro sarcoma etc.
Here below is an example for fibro sarcoma HT-1080:

IMG

—————

ANTIANGIOGENETIC ACTION
This synergy of essential cellular nutrients also has anti-angiogenetic properties.

IMG XXXXXXXXXXXXXXX XXXXXXXXXXXXXXX

Essential cellular nutrients have led to a reduced migration of endothelial cells (see fig. A – right) and a reduced secretion of endothelial growth factor in blood vessels (see fig. B – below).
These make up two essential stages in the formation of new blood vessels in tumours (angiogenesis).

CANCER CELL DEATH
The synergy of essential cellular nutrients, employed in Dr. Rath’s programme, can remove different types of cancer cells, without damaging normal cells. This approach is different from chemotherapy that destroys both cancer and healthy cells.

Synergy of essential cellular nutrients in tumours

IMG XXXXXXXXXXXXXXX XXXXXXXXXXXXXXX

These observations show that the synergy of essential cellular nutrients may represent a decisive therapy method in cancer treatment.
All tumour types exploit the collagen assimilation mechanism to spread in the body, thus this synergy has been proved effective against many types of cancer.
Experiments performed on bare mice have shown that the combination of essential cellular nutrients in cases of melanoma, prostate and colon cancer.
After only four weeks of these essential cellular nutrients, the mice had reduced tumour growth by 60- 80 per cent.
The therapeutic association of essential cellular nutrients is strengthened by the number of steadily increasing witness reports that confirm the results of total disappearance of prostate, lung and brain cancer. Successful results have also been reported for colon, breast, testicle, bladder, bone, ovary and pancreas cancer. For further information, visit the internet site www.dr-rath-research.org. XXXXXXXX XXXXXXXXXXXXXXX

IMG XXXXXXXXXXXXXXX XXXXXXXXXXXXXXX

The therapeutic association of essential cellular nutrients is strengthened by the number of steadily increasing witness reports that confirm the results of total disappearance of prostate, lung and brain cancer. Other studies have been planned to clinically assess the action of this synergy of essential cellular nutrients.

Why are some cancer types more widespread?
About 90% cancer deaths are caused by metastasis. For this reason, it is extremely important to analyse this process connected to the secretion of enzymes, matrix metalloproteinase (MMP), which allows the spreading of cancer cells. Cancer cell aggressiveness may be measured on MMP activity.
The capacity of some cells to produce large amounts of enzymes may explain why some organs are more prone to cancer, for instance ovaries and breasts. The cells of these organs naturally secrete MMP, necessary for ovulation and to “structure” the breast for milk production during breast-feeding.
In the same way, white blood cells use enzymes that assimilate the matrix to construct a path through the connective tissue towards the infection site.
If a cell becomes malignant inside an organ, the organ is immediately able to secrete large quantities of MMP to strengthen its growth further and thus its invasive potential. The increased MMP production promotes breast and ovary cancer, as well as leukaemia, differently to other organs that have a lesser natural capacity of biodegrade the collagen matrix.

PREVENTION
Many cancer pathologies are linked to life styles we lead. The risk of cancer may be affected by our nutrition, body weight, physical exercise and smoking, which are all variables that can be controlled. It is difficult to predict the emergence of cancer in an individual but it is possible to implement prevention actions to reduce risks. Here below is a risk reducing guide line based to our research and other clinical and scientific results:
1. Eat in a balanced and varied manner, favouring vegetal food. Avoid food contaminated with pesticides, growth hormones or antibiotics.
2. Supplement daily nutrition with essential cellular nutrients. Vitamin C and lysine are particularly important as they are of extreme importance in extracellular matrix stability. These cellular nutrients are not produced by the human body and thus have to be externally supplemented in the required quantities.
3. Get to know family members’ health conditions to identify any genetic risk factors or other diseases and to implement due preventive actions and minimise risks.
4. Lead a healthy life style. Practise physical exercise regularly and keep body weight under control.
5. Do not smoke and avoid passive smoke, too.
6. Try to reduce stress with relaxation techniques.
7. In the case of any medication, discuss the possibility of lower dosage and duration with your physician. Get to know side effects and interactions. In many cases, it is sufficient to take dietary supplements to reduce side effects and speeden recovery.
8. Learn to know your body and its healthy food needs. Your body needs your help!

ABOUT THE AUTHORS

Dr. Matthias Rath is the founder cellular medicine.
Cellular medicine traces the majority of diseases the currently distress the population to the underfeeding of millions of cells that do not receive sufficient cellular nutrients i.e. vitamins, amino acids, minerals and other particular substances.
Dr. Rath has made important scientific discoveries to defeat heart attacks. Thanks to these discoveries, it is possible to prevent infarct and ictus. Dr. Rath’s researches have contributed to innovative discoveries in combating cancer.
These researches have allowed a decoding of molecular processes that lead to blocking tumour growth thus avoiding metastasis in the body.

Dr. Aleksandra Niedzwiecki is vice-president of Matthias Rath Inc. and director of the research division. As director, Dr. Niedzwiecki actively takes part in the development and expansion of research in cellular medicine.
In biomedicine, she plays a fundamental role in continuous development of therapies with nutritional substances for disease therapy. She graduated in biochemistry at Warsaw University, Poland.
Dr. Niedzwiecki has held important positions at the research faculties of: Rockefeller University in New York, University of Toronto, Linus Pauling Institute for science and medicine (once in Palo Alto, California).
She has collaborated directly with Nobel Prize Linus Pauling and G.M. Edelman, has published over 70 scientific articles in renowned specialized magazines, and has collaborated in the drafting of books and various articles on research. She has also been invited as speaker to numerous scientific conferences and meetings.
Dr. Niedzwiecki has been collaborating closely with Dr. Rath in research and development of cellular health therapies for over ten years. Furthermore, she is a member of the American College of Nutrition, American Cardiac Association, American Medical Women’s Association, American association of cellular biology and other organisations.

Dr. M. Waheed Roomi has a PhD in biochemical toxicology from Surrey University, England, certified by the American Board of Toxicology and the American College of Clinical Nutrition.
Dr. Roomi worked at the Linus Pauling Institute for five years, before joining Matthias Rath Inc. as head researcher since 2000.
His major researches include cancer, drug metabolism, professional and environmental toxicology, organic synthesis, toxicity molecular, free radicals and oxidation damages.
Dr. Roomi has published about 100 articles in international magazines and has attended over 125 national and international meetings. He is a member of American Association of Cancer Research, Federation of American Societies of Experimental Biology, Society of Toxicology and American Society of Clinical Pathology.

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